|Oscroft NS et al. A randomised crossover trial comparing volume assured and pressure preset noninvasive ventilator in stage hypercapnic COPD. COPD: Journal of Chronic Obstructive Pulmonary Disease 2010;7:398–403.
|Stable hypercapnic COPD, PSV users
||iVAPS comparable to PSV; PaO2, PaCO2, mean nocturnal oxygenation, lung function, exercise capacity, mean nocturnal tcCO2, health status, compliance equivalent.
|Jaye J et al. Autotitrating versus standard noninvasive ventilation: a randomised crossover trial. Eur Respir J 2009;33:566–573.
||Stable neuromuscular disease/chest wall, PSV users
||iVAPS comparable to PSV; nocturnal oxygenation, sleep efficiency, arousals, HR variability equivalent. Slight increase in tcCO2 and decrease in stage 1 sleep.
|Battisti A et al. Automatic adjustment of noninvasive pressure support with a bilevel home ventilator in patients with acute respiratory failure: a feasibility study. Intensive Care Med 2007;33:632–638.
||Acute respiratory failure in hypercapnic, stabilized PSV users
||iVAPS comparable to PSV; PaCO2 and pH improvements, minute volume, pressure support, respiratory rate, hemodynamics equivalent.
|Oscroft NS et al. Volume assured versus pressure preset non-invasive ventilation for compensated ventilatory failure in COPD. Resp Med 2014;108:1508–1515.
||COPD patients with compensated ventilatory failure; naïve to NIV
||iVAPS comparable to PSV; PaO2, PaCO2, mSpO2 and therapy compliance equivalent at 3 months. Time spent in hospital initiating to NIV shorter with iVAPS.
|Kelly JL et al. Randomized trial of ‘intelligent’ autotitrating ventilation versus standard pressure support non-invasive ventilation: Impact on adherence and physiological outcomes. Respirology 2014;19:596–603.
||Chronic obstructive or Restrictive lung disease; naïve to NIV
|iVAPS comparable to PSV; mSpO2, tcCO2, spirometry, respiratory muscle strength, sleep quality, arousals, O2 desaturation index equivalent. Increase in therapy adherence [>60 minutes) and decrease in median PS with iVAPS.
|Ekkernkamp E et al. Impact of intelligent volume assured pressure support on sleep quality, compliance and gas exchange in patients with stable hypercapnic COPD. Eur Resp J 2012;40(56):2064.
||Stable hypercapnic COPD; PSV users
||iVAPS comparable to PSV; Subjectively reported increase in sleep quality with iVAPS. Greater decrease in tcCO2 on iVAPS vs PSV.
|Banerjee S et al. Volume assured pressure support ventilation for chronic ventilatory failure in COPD. Eur Respir J 2012;40(56):2068.
||COPD patients in chronic ventilatory failure
||iVAPS comparable to PSV; trend towards shorter time initiative NIV with iVAPS.
|Jaye J et al. Initiation of nocturnal ventilation using an intelligent autotitrating non-invasive ventilator: Impact on ventilatory efficiency, sleep and adherence. Eur Resp J 2012;40(56):2852.
|Chronic obstructive or restrictive lung disease and new diagnosed nocturnal hypoventilation
||iVAPS was found to help patients adhere to therapy for 60 minutes longer (per session) than when treated with standard pressure support ventilation.