Clinical evidence for iVAPS
iVAPS' efficacy and tolerability have been established in eight studies.
Study | Sample size | Patient population | Outcome |
---|---|---|---|
Oscroft et al.1 | 25 |
Stable hypercapnic COPD, PSV users | iVAPS comparable to PSV; PaO2, PaCO2, mean nocturnal oxygenation, lung function, exercise capacity, mean nocturnal tcCO2, health status, compliance equivalent. |
Jaye et al.2 | 18 | Stable neuromuscular disease/chest wall, PSV users | iVAPS comparable to PSV; nocturnal oxygenation, sleep efficiency, arousals, HR variability equivalent. Slight increase in tcCO2 and decrease in stage 1 sleep. |
Battisti et al.3 | 19 | Acute respiratory failure in hypercapnic, stabilized PSV users | iVAPS comparable to PSV; PaCO2 and pH improvements, minute volume, pressure support, respiratory rate, haemodynamics equivalent. |
Oscroft et al.4 | 40 | COPD patients with compensated ventilatory failure; naïve to NIV | iVAPS comparable to PSV; PaO2, PaCO2, mSpO2 and therapy compliance equivalent at 3 months. Time spent in hospital initiating to NIV shorter with iVAPS. |
Kelly et al.5 | 18 | Chronic obstructive or Restrictive lung disease; naïve to NIV |
iVAPS comparable to PSV; mSpO2, tcCO2, spirometry, respiratory muscle strength, sleep quality, arousals, O2 desaturation index equivalent. Increase in therapy adherence [>60 minutes) and decrease in median PS with iVAPS. |
Ekkernkamp et al.6 | 27 | Stable hypercapnic COPD; PSV users | iVAPS comparable to PSV; increase in MV with therapy equivalent to PSV. |
Ekkernkamp et al.7 | 14 | Stable hypercapnic COPD; PSV users | iVAPS comparable to PSV; Subjectively reported increase in sleep quality with iVAPS. Greater decrease in tcCO2 on iVAPS vs PSV. |
Banerjee et al.8 | 40 | COPD patients in chronic ventilatory failure | iVAPS comparable to PSV; trend towards shorter time initiative NIV with iVAPS. |
COPD: chronic obstructive pulmonary disease; NMD: neuromuscular disease; PaCO2: arterial carbon dioxide pressure; PaO2: arterial oxygen pressure; PSV: pressure support ventilation; tcCO2: transcutaneous carbon dioxide; HR: heart rate; mSpO2: mean blood oxygen saturation; PS: pressure support; MV: minute ventilation.