Clinical evidence for iVAPS

iVAPS' efficacy and tolerability have been established in eight studies.

Study Sample size Patient population Outcome
Oscroft et al.1 25

 Stable hypercapnic COPD, PSV users iVAPS comparable to PSV; PaO2, PaCO2, mean nocturnal oxygenation, lung function, exercise capacity, mean nocturnal tcCO2, health status, compliance equivalent.
Jaye et al.2 18 Stable neuromuscular disease/chest wall, PSV users iVAPS comparable to PSV; nocturnal oxygenation, sleep efficiency, arousals, HR variability equivalent. Slight increase in tcCO2 and decrease in stage 1 sleep.
Battisti et al.3 19 Acute respiratory failure in hypercapnic, stabilized PSV users iVAPS comparable to PSV; PaCO2 and pH improvements, minute volume, pressure support, respiratory rate, haemodynamics equivalent.
Oscroft et al.4 40 COPD patients with compensated ventilatory failure; naïve to NIV iVAPS comparable to PSV; PaO2, PaCO2, mSpO2 and therapy compliance equivalent at 3 months. Time spent in hospital initiating to NIV shorter with iVAPS.
Kelly et al.5 18 Chronic obstructive or Restrictive lung disease; naïve to NIV

 iVAPS comparable to PSV; mSpO2, tcCO2, spirometry, respiratory muscle strength, sleep quality, arousals, O2 desaturation index equivalent. Increase in therapy adherence [>60 minutes) and decrease in median PS with iVAPS.
Ekkernkamp et al.6   27 Stable hypercapnic COPD; PSV users iVAPS comparable to PSV; increase in MV with therapy equivalent to PSV.
Ekkernkamp et al.7   14 Stable hypercapnic COPD; PSV users iVAPS comparable to PSV; Subjectively reported increase in sleep quality with iVAPS. Greater decrease in tcCO2 on iVAPS vs PSV.
Banerjee et al.8 40 COPD patients in chronic ventilatory failure iVAPS comparable to PSV; trend towards shorter time initiative NIV with iVAPS.

 

COPD: chronic obstructive pulmonary disease; NMD: neuromuscular disease; PaCO2: arterial carbon dioxide pressure; PaO2: arterial oxygen pressure; PSV: pressure support ventilation; tcCO2: transcutaneous carbon dioxide; HR: heart rate; mSpO2: mean blood oxygen saturation; PS: pressure support; MV: minute ventilation.

References